The energy sector dropped 1.3% following a fall in oil prices as a bond price rout led to gains in the US dollar. Crude supply is expected to rise in response to prices climbing above pre-pandemic levels.
The materials sector, which includes precious and base metals miners and fertilizer companies, lost 1.1% as gold futures fell 0.9% to $1,757.8 an ounce.
Domestic retail sales fell 3.4% in December to $53.38 billion ($42.37 billion), the biggest monthly drop since April, as COVID-19 restrictions hit businesses, Statistics Canada said.
Toronto Stock Exchange's S&P/TSX composite index was flat at 18,274.68 and was set to record its worst week so far this month.
The Toronto Stock Exchange's S&P/TSX composite index ended 0.6% lower at 18,374.78 on Wednesday.
Dow e-minis were down 77 points, or 0.24% at 7:00 a.m. ET, while S&P 500 e-minis were down 15.5 points, or 0.39% and Nasdaq 100 e-minis were down 102.5 points, or 0.75%.
The healthcare sector shed 1.7%, as cannabis companies including Aphria Inc, Cronos Group, and Hexo Corp fell over 1% in early trade.
The financials sector gained 0.7%, led by the largest percentage gainers on the index, CI Financial Corp and iA Financial Corporation Inc, which jumped 6.8% and 4.1% respectively.
The materials sector, which includes precious and base metals miners and fertilizer companies, added 0.9% as gold futures rose 1.2% to $1,833.4 an ounce.
Toronto Stock Exchange's S&P/TSX composite index was up 126.16 points, or 0.7%, at 18,262.06.
The Toronto Stock Exchange's S&P/TSX composite index was up 230.66 points, or 1.33%, at 17,567.68.
The materials sector, which includes precious and base metals miners and fertilizer companies, added 3.9% as gold futures rose 1.0% to $1,865.5 an ounce.
Toronto Stock Exchange's S&P/TSX composite index was down 140.15 points, or 0.79%, at 17,517.05. On Wednesday it had jumped 1.3% to post its best day in over two months.
Canada said on Thursday it expects a further delay in Pfizer Inc's COVID-19 vaccine deliveries in the next few weeks.