Messi had twice been sent off playing for Argentina, including at the 2019 Copa America, but never in 16 years and 753 matches with Barcelona's first team.
Sociedad, who made a blistering start to the La Liga season but have since faded, ran their hearts out to keep Barca at bay in a tight match before the game opened up in extra time, when both sides came close to finding a winner.
Messi caused consternation at Barca when he sent the club a burofax (official notice) that he wanted to leave in August.
Everything that happened before the summer, how the season ended, then the burofax and everything else... I dragged everything into the start of the season a bit.
The Catalans have endured an inconsistent season so far, losing four times already in the league, and sit six points off pacesetters Atletico Madrid, Real Sociedad and Real Madrid.
Under the terms of the agreement, Reig Jofre said it will be responsible for the formulation, filling and packaging of the vaccine, while Janssen will handle distribution.
Shares in the Spanish group surged 17% in early trade to 4.41 euros ($5.35) a share.
"There could have been about 200 people (in the warehouse)," La Vanguardia quoted the mayor as saying, adding the number of people who stayed there fluctuated from day to day.
His game was perhaps best summed up when, into the final 10 minutes with his team comfortably leading, Ronaldo tracked back and dispossessed Messi inside the Juve box before leading the charge on a counter-attack.
The 33-year-old was captured shedding tears as he briefly put his head down while he drove out of and away from the Ciutat Esportiva Joan Gamper facilities.