The only surviving former winners of European club football's greatest prize – with five titles each – meet in a heavyweight Champions League quarter-final behind closed doors at the Estadio da Luz.
Cristiano Ronaldo could face his former team Real Madrid in the Champions League quarter-finals as the draw for the rest of the tournament was made on Friday.
Unless Barca's displays for the remainder of the 2019-20 campaign have a significant upswing, it is understood that it is inevitable Setien will leave his post in the summer.
The Spanish top flight recommences on Thursday following a three-month break enforced by the coronavirus pandemic, with league leaders visiting Real Mallorca on Saturday.