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World

English variant not linked to more serious infections: study

  • However they said the Lancet study had the benefit of having used whole-genome sequencing as well as a good variety of patient and disease outcomes.
Published April 13, 2021

PARIS: The English variant of the novel coronavirus does not increase the severity of Covid-19 compared to other strains, according to research published Tuesday that also confirmed its increased transmissibility.

The variant, known as B117, is now the dominant viral strain across much of Europe, and previous studies had shown it was linked to a higher likelihood of death than normal variants.

But two studies published in The Lancet Infectious Diseases and The Lancet Public Health journals found no evidence that people with B117 experience worse symptoms or a greater risk of developing long Covid than those infected with different variants.

The research found however that the variant was associated with a higher viral load and reproduction rate than normal variants.

Authors of the first study looked at data from 341 patients who tested positive for Covid-19 late last year when B117 was running rampant across southeast England.

They found that 58 percent of those patients had B117, while 42 percent had non-B117 Covid-19.

Of those infected with B117, 36 percent became severely ill or died, compared with 38 percent of those with non-B117, suggesting that there was no association between B117 and heightened risk of severe infection.

Patients with the variant tended to be younger, and infections of B117 occurred more frequently in ethnic minority groups, the data showed.

The authors also analysed the transmissibility by looking at data generated by PCR testing. They found that samples of B117 tended to contain greater quantities of the virus than non-B117 swabs.

Commenting on the first study, Sean Wei Xiang Ong, Barnaby Edward Young and David Chien Lye from the National Centre for Infectious Diseases, Singapore, said that the findings were in contrast to three previous studies suggesting that B117 was deadlier than other variants.

However they said the Lancet study had the benefit of having used whole-genome sequencing as well as a good variety of patient and disease outcomes.

"The finding that lineage B117 infection did not confer increased risk of severe disease and mortality in this high-risk cohort is reassuring but requires further confirmation in larger studies," said the experts, who were not involved in the research.

A second study analysed self-reported data from 36,920 British users of a Covid-19 symptom app who tested positive between September 28 and December 27 last year.

They found that the B117 variant had a reproduction rate 1.35 times higher than normal coronavirus variants, but also found no evidence of increased disease severity.

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