"There are significant issues that must be overcome if this is to be a success, with investment ahead of time and profits unlikely until after 2025 if not later," Atlantic Equities analyst Ianjit Bhatti said.
"In the near term (2-3 years), we do not believe that Intel has an answer to AMD's market share gains."
Futures: Dow and Nasdaq drop 0.47%, S&P down 0.49%.
After blockbuster earnings from major US banks last week, analysts expect first-quarter profit for overall S&P 500 firms to jump 30.9% from a year earlier, according to Refinitiv IBES data.
Net revenue rose to $9.02 billion in the first quarter, from $8.60 billion a year earlier, above analysts' average estimate of $8.63 billion, according to IBES data from Refinitiv.
Net income attributable to the company's shareholders fell to $2.25 billion, or 52 cents per share, from $2.78 billion, or 64 cents per share, a year earlier.
The increases in many of these so-called value stocks have slowed lately, while U.S. Treasury prices have come galloping back in April after a sharp first-quarter sell-off.
The Wall Street powerhouse, however, recorded a total one-off loss of over $900 million that it said was related to a credit event and subsequent losses from "a single prime brokerage client."
Morgan Stanley was one of six banks who had exposure to Archegos Capital Management, a family office fund that defaulted on margin calls late last month and triggered a firesale of stocks across Wall Street.
The second-largest US bank by assets unlocked $2.7 billion from its reserves and unveiled a $25 billion stock repurchase plan, betting on a swift economic recovery driven by rapid vaccinations.
Consumer banking revenue at the bank, however, fell 12% to $8.1 billion in the quarter ended March. Net interest income, a key measure of how much the bank can make from lending, fell 16% to $10.2 billion in the quarter.
Overall investment banking revenue rose 73% to $3.77 billion, its highest since 2010, while equities trading surged 68% as a jump in trading by ordinary investors fed stock market volatility.
Global investment banking fee hit an all-time record of $39.4 billion during the March quarter, according to Refinitiv data.
All three major U.S. stock indexes gained some ground and the S&P 500 and the Dow were last in positive territory, with economically-sensitive small caps and transports lagging.
The company said it would sell up to 3.5 million shares and use the proceeds to speed up the shift in its business model to e-commerce in an overhaul being led by top shareholder and board member Ryan Cohen.
GameStop's stock has gained more than 900% so far this year, giving the company a valuation of as much as $34 billion at one point as retail traders bet against Wall Street hedge funds that had shorted its shares.