Lufthansa also confirmed its target to reach 40% capacity level for the entire year 2021, with the operating loss significantly below last year's nearly 5.5 billion euros
The EU will also shut out the Belarusian carrier Belavia from its skies and airports. Lufthansa, KLM, SAS, Air France, LOT and Singapore Airlines were among carriers that announced they would stop flying over Belarus.
"Airlines avoiding the airspace of Belarus may well have an additional time and fuel cost, depending on the route. Longer haul routes will generally be relatively less affected."
Germany's largest airline said it was planning to add around 20 new destinations from Frankfurt and 13 from Munich to locations such as the Caribbean, the Canary Islands and Greece.
COVID-19 vaccines and testing, along with strict hygiene rules at airports and on planes, will be prerequisites for travel this summer, it said.
Lufthansa was granted a 9 billion euro ($10 billion) government bailout that came with conditions to preserve competition including the transfer to rivals of some take-off and landing slots at German airports.
Earlier this month, Condor asked the European Court of Justice to stop Lufthansa from cancelling the agreement.
The airline is still hoping for a strong travel recovery from the northern summer onwards, Spohr added, and expects to run at 40-60% of pre-crisis capacity for the year as a whole.
A growing list of countries are limiting travel to and from South Africa since a more transmissible variant of the virus, dubbed 501Y.V2, was announced in December.
Emirates this week announced a 13-day halt on all South Africa routes for "operational reasons".
Like its rivals, Lufthansa is struggling to deal with global travel restrictions and grounded fleets in the wake of the coronavirus pandemic.
Lufthansa is ruling out layoffs of pilots for operational reasons at Lufthansa, Lufthansa Cargo, Lufthansa Aviation Training and a subgroup of Germanwings pilots until March 2022.
Only those testing negative or able to provide evidence of a negative test within the previous 48 hours will be allowed to board.
The carrier will use the tests for two daily flights between Munich and Hamburg from Nov. 12 onwards to see how the test procedure can be included in the pre-flight routine.
First-quarter capacity is expected to be up to 25% of pre-crisis levels, unchanged from the current quarter and well short of the 50% previously envisaged by the end of this year.
Business customers, traditionally the carrier's cash cow, remain a rarity but are returning on the carrier's China routes.
Lufthansa said it would also cut the investment volume for new aircraft in half, with its financial plan allowing for up to 80 new aircraft for the group's fleet up to 2023.
Lufthansa already decided in early April to reduce its fleet by 100 aircraft and not to resume the operations of budget unit Germanwings.