New drug reverses memory loss caused by depression, Alzheimer’s

Scientists have developed a new experimental drug to reverse memory loss in the elderly caused by diseases such as depression or Alzheimer’s.

People suffering from mental illnesses can lead to poor memory. A new research by Canadian scientists has found that it might soon be possible to restore brain cells as they used to be in their youth.

The drug is a ‘tweaked’ version of benzodiazepiene – the anti-anxiety and depression drug Valium. But, unlike Valium, this drug is able to specifically target impairments in brain cells related to memory. The research is hoped to produce a daily pill that could keep older brains sharp and a potential treatment for the mild cognitive impairment seen in early stages of Alzheimer’s disease, reported Daily Mail.

New blood test can predict Alzheimer’s disease 30 years in advance

The drug has only been tested in mice who had undergone stress for now, but clinical human trials of the drug are expected to take place within two year. However, it showed promising results in ageing mice, improving their memories to the levels seen in much younger animals.

During the tests, 30 minutes after the treatment, the mice performed at normal levels in their abilities to remember the layout of mazes. Also, in another experiment, memory declines seen in ageing mice were rapidly reverse and performance increase to 80% after the drug was given.

Lead scientist Etienne Sibille, said, “The aged cells re-grew to appear the same as young brain cells, showing that our novel molecules can modify the brain in addition to improving symptoms. We’ve shown that our molecules enter the brain, are safe, activate the target cells and reverse the cognitive deficit of memory loss.”

Sibille said, “Our findings have direct implications for poor cognition in normal aging. This would include learning and memory, executive functions, decision making, and planning.”

“Looking into the future, one may suggest anybody over the age of 55-60 years of age who may be at risk of cognitive problems later on, could benefit from this treatment.,” he concluded.