Akeso lung cancer drug helps patients live 15pc longer than immunotherapy in China trial

BEIJING: An experimental drug developed by China-based Akeso helped patients with advanced squamous non-small cell lung cancer live 15 percent longer than BeOne Medicines’ immunotherapy Tevimbra, and cut the risk of death by more than one-third in a study presented at a medical meeting on Sunday.

Patients who received ivonescimab and chemotherapy lived an average of 27.9 months, compared with 23.7 months for those who received Tevimbra and chemotherapy, according to a brief summary of the study results.

The company had reported in October that ivonescimab met the main goal of the study, showing that it cut disease progression or death by 40% versus Tevimbra, before the overall survival data was available.

The head-to-head study conducted in China involved 532 patients with newly diagnosed advanced stage 3 or stage 4 squamous non-small cell lung cancer. It compared ivonescimab with Tevimbra as an initial, or first-line, treatment. All patients also received chemotherapy.

The results are being presented at the American Society of Clinical Oncology meeting in Chicago on Sunday.

Dr. David Spigel, chief scientific officer of the Sarah Cannon Research Institute in Nashville, Tennessee, said during a press briefing on Saturday it is not clear if the trial in China will translate to a wider population because differences in ethnicity sometimes affect how drugs work. But, he said, the results are “very encouraging.”

Ivonescimab belongs to a newer class of medicines known as bispecific antibodies, which have dual targets. It blocks the protein PD-1 that helps cancer avoid immune system attack and a second protein called VEGF that can promote tumor growth.

Tevimbra, like other widely used immunotherapies such as Merck’s Keytruda, is a monoclonal antibody that targets PD-1.

The company said with the improved survival data from the dual-target approach and the drug’s favorable risk-benefit profile, it should become the new standard of care in the management of advanced squamous NSCLC.

About 69 percent of people given the drug experienced serious side effects versus 59 percent given the standard treatment arm. About 5 percent of people stopped treatment due to side effects in both groups, according to the publication in the medical journal The Lancet.