Israeli forces have stormed the Al-Aqsa Mosque compound, launching tear gas, rubber bullets and stun grenades at worshippers, risking the longevity of the newly-agreed ceasefire.
Several injuries are being reported, as worshippers come under siege from Israeli forces.
According to the Palestinian Ministry of Health, at least 21 civilians have been killed by Israeli air raids on the besieged Gaza Strip, after Hamas launched retaliatory rockets from the coastal territory.
The aerial bombardment occurred after Hamas fired several rockets at Israel, after Israel refused to withdraw forces from the Al Aqsa Mosque in Jerusalem.
Israel has responded with 130 strikes carried out by fighter jets and attack helicopters on military targets in the enclave, killing 15 commanders from Hamas, said Conricus.
The violence was the latest in days of the worst such disturbances in Jerusalem since 2017, fuelled by a long-running bid by Jewish settlers to take over nearby Palestinian homes in Israeli-annexed east Jerusalem.