At least two people were killed and 57 injured on Wednesday when a passenger express train derailed near Tando Adam, railway and rescue officials said.
Four coaches of the train derailed, said Allah Rakhio Mirani, a police official for Pakistan Railways.
"Two passengers have been killed and 30 injured in the incident," he said.
The train, Tezrao, travelling from Karachi to Rawalpindi, jumped the tracks near Tando Adam, he said.
"We still don't know the cause of the accident, but there is a possibility of sabotage because someone may have removed steel plates from the track," a witness said.
Karmoo, 80, and another unidentified person were killed.
Bogo Khan, an official of the Edhi Foundation, said ambulances had taken the injured passengers to a hospital in Hyderabad. The seriously injured people were shifted to Civil Hospital, Nawabshah.
Of the 57 injured, 11 were seriously wounded and were moved to hospitals in Hyderabad.
Some of the rear carriages left the track as the train entered Tando Adam railway junction, provincial minister Naeem Ishtiaq told AFP.
Movement of trains from Punjab to Karachi remained suspended for hours.
Meanwhile, Minister for Railways Ghous Bakhsh Mahr has ordered an inquiry to ascertain the cause of the derailment of Tezro. This was stated by divisional superintendent Pakistan Railways, Rawalpindi Muhammad Ishfaq Khattak while talking to PTV.
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