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Stocks were also pressured by revived trade war fears on a report that President Donald Trump's administration would proceed with tariffs on Chinese goods.
At the closing bell, the Dow Jones Industrial Average was down 0.5 percent at 25,203.92.
The broad-based S&P 500 shed 0.4 percent to 2,775.74, while the tech-rich Nasdaq Composite Index dipped 0.1 percent to 7,693.89, retreating from Tuesday's record.