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The Hang Seng Index, which was closed Tuesday for May Day, slipped 0.27 percent or 84.57 points to close at 30,723.88.
The benchmark Shanghai Composite Index was marginally lower, inching down 1.05 points to 3,081.18. The Shenzhen Composite Index, which tracks stocks on China's second exchange, eased 0.07 percent, or 1.23 points, to 1,774.90.