Mnuchin said in an interview that aired on Monday that American officials planned to raise intellectual property rights, joint technology and joint ventures with Chinese officials.
"We're looking to have a very frank discussion on trade, on the issues of the trade imbalance," he said ahead of remarks due later on Monday at a conference in Beverly Hills, California.
China has said it is open to trade negotiations with the United States after US President Donald Trump proposed imposing tariffs on $50 billion in Chinese exports and threatened additional tariffs of $100 billion. China, in response, said it will impose its own tariffs on American products.
Asked about concerns over possible retaliatory measures by China, Mnuchin said: "It's not a worry of mine," adding that Trump was focused on "free and fair and reciprocal trade."
The US Treasury Secretary will be joined on the high-stakes trip by US Trade Representative Robert Lighthizer, White House trade adviser Peter Navarro and White House economic adviser Larry Kudlow.
Chinese Vice Premier Liu He will be part of this week's meeting, Mnuchin told the network.