Nike Inc shares fell 2.5 percent after the company forecast muted growth in current-quarter revenue, reflecting its struggles in the North American market.
UnitedHealth Group Inc was down 0.7 percent after the health insurer agreed to buy Chilean healthcare company Banmedica SA for $2.8 billion.
Investors are winding down ahead of the Christmas holiday on Monday, when the market will be closed.
"It's been a strong week," said Mark Luschini, chief investment strategist at Janney Montgomery Scott in Philadelphia. "Whether the market is up a little bit or down a little bit is not indicative of larger trends...It's easy to push things around when not many people are trading."
Indeed, major Wall Street indexes were on track to end the week higher, buoyed by a historic overhaul of the US tax code.
President Donald Trump signed Republicans' massive $1.5 trillion tax overhaul into law on Friday and also approved a short-term spending bill that averts a possible government shutdown.
The Dow Jones Industrial Average fell 36.02 points, or 0.15 percent, to 24,746.27, the S&P 500 lost 1.9 points, or 0.07 percent, to 2,682.67 and the Nasdaq Composite dropped 6.03 points, or 0.09 percent, to 6,959.33.
Wildly volatile bitcoin plunged below $12,000, losing around a third of its market value in five days. It since has stabilized above $13,000. Companies that have been riding the bitcoin wave were hit hard by the cryptocurrency's slump.
Long Blockchain Corp, Overstock.com Inc, Riot Blockchain Inc and Marathon Patent Group Inc tumbled between 2 percent and 15 percent.
Data on Friday showed US consumer spending went up in November and shipments of key capital goods orders increased for the 10th straight month, confirming strong economic momentum.
"The data is relatively mixed but biased to the upside, and consumer sentiment continues to be strong and that bodes well for economic strength in 2018," said Matthew Miskin, market strategist at John Hancock Investments in Boston, Massachusetts.
The benchmark S&P has climbed about 20 percent this year and is on track for its best performance since 2013 on solid corporate earnings, strong economic fundamentals, upcoming cuts to corporate tax rates and hopes of looser regulations.
Real estate led the S&P 500 in gains, with a 0.7 percent rise. Health was the biggest decliner, falling 0.4 percent.
Celgene Corp shares fell 1.9 percent after the company's follicular lymphoma regimen failed in a clinical trial.
Advancing issues outnumbered declining ones on the NYSE by a 1.15-to-1 ratio; on Nasdaq, a 1.27-to-1 ratio favored decliners.