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"She did the pre-race inspection this morning, but decided against racing," a US team spokesperson said.
"She's packed up and already left Val d'Isere. She won't race in Courchevel."
"She will now head home to the US to spend Christmas there."
The 33-year-old star of the circuit who won Saturday's super-G said the move had been one of precaution.
"Knee is a bit sore from yesterday so to be on the safe side I'm going to give my body some rest. My focus is on the Olympics so no need to risk anything now. Still going home very happy after my win yesterday," Vonn wrote on Twitter.
Vonn had to withdraw from a super-G in St Moritz last weekend with a back injury, for which she had treatment in Austria.