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Nasir Jamal and Rahmat Shah notched half centuries to lead Afghanistan to 238-9 in their 50 overs after they were put in to bat by Ireland, while teenage star Rashid Khan added 48.
Sixteen-year-old off-spinner Mujeeb Zadran took 4-24 -- the joint-best figures for an Afghan bowler on ODI debut -- to help dismiss Ireland for 100 in 31.4 overs.
The second match is also in Sharjah on Thursday.