Flanker Michael Hooper will captain the side in which prop Sekope Kepu win his 90th cap.
Former skipper and seasoned hooker Stephen Moore -- due to retire from test rugby at the end of the tour -- could become the seventh-most capped player of all time with 128 if he comes on for Tatafu Polota-Nau during the match.
Cheika's side, emboldened by their 29-21 victory over the Welsh last Saturday, will be seeking to record their first win over England since the pool match in the 2015 World Cup.
Team (15-1)
Kurtley Beale; Marika Koroibete, Tevita Kuridrani, Samu Kerevi, Reece Hodge; Bernard Foley, Will Genia; Sean McMahon, Michael Hooper (capt), Ned Hanigan; Adam Coleman, Rob Simmons; Sekope Kepu, Tatafu Polota-Nau, Scott Sio
Replacements (one to be omitted, 16-24): Stephen Moore, Tom Robertson, Allan Alaalatoa, Matt Philip, Ben McCalman, Lopeti Timani, Nick Phipps, Karmichael Hunt, Henry Speight
Coach: Michael Cheika (AUS)