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The Hang Seng Index closed down 0.30 percent, or 68.20 points, at 22,608.49.
The benchmark Shanghai Composite Index was flat, edging up 0.60 points to 3,241.74. The Shenzhen Composite Index, which tracks stocks on China's second exchange, lost 0.38 percent, or 8.02 points, to 2,121.49.