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The Hang Seng Index fell 1.37 percent, or 308.87 points, to end at 22,222.22.
But the benchmark Shanghai Composite Index gained 0.45 percent, or 14.33 points, to 3,210.37 while the Shenzhen Composite Index, which tracks stocks on China's second exchange, rose 0.30 percent, or 6.27 points, to 2,114.30 on turnover of 421.0 billion yuan.