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The benchmark Hang Seng Index dropped 63.62 points to 23,779.62 on turnover of HK$69.97 billion ($8.99 billion).
In Shanghai, the Composite Index rose 1.49 percent as gains in resource stocks outweighed losses in the real estate sector, dealers said.
The Shanghai Composite Index, which covers both A and B shares, was up 40.34 points at 2,749.15 on turnover of 115.2 billion yuan ($17.5 billion).