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Pakistan won the fourth match in Durban by three wickets to level the series at 2-2.
Fast-bowler Umar Gul, who missed the final ODI due to a knee injury, has been ruled out of the series.
South Africa:
AB de Villiers (capt, wkt), Hashim Amla, Quinton de Kock, Colin Ingram, David Miller, Farhaan Behardien, Ryan McLaren, Robin Peterson, Dale Steyn, Morne Morkel, Lonwabo Tsotsobe.
Pakistan:
Misbah-ul-Haq (capt), Mohammad Hafeez, Imran Farhat, Kamran Akmal (wkt), Younis Khan, Shoaib Malik, Shahid Afridi, Saeed Ajmal, Junaid Khan, Wahab Riaz, Mohammad Irfan.