Frenchman Konate, 22, will join the Anfield club on July 1 once his work permit application is approved and medicals are completed.
Financial details of the transfer were not revealed but British media reported Liverpool triggered a 41 million euros ($49.82 million) release clause in his contract. Konate had a contract until June 2023 with Leipzig.
"Let me try to win at Crystal Palace... United is an extraordinary team arriving in the last two months in their best form of the season and we need five points to be champions," Guardiola, whose side beat Paris St Germain 2-1 in the Champions League in midweek, told reporters on Friday.
"All we can do now is recover as well as possible from the physically and mentally tough game we played in Paris. It is our sixth game in a row away. It is a lot of travel and we are tired in many aspects.