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Two missiles hit Datta Khel town, some 40 kilometres (25 miles) west of Miranshah, the main town in North Waziristan tribal district, which borders Afghanistan and is a stronghold of Al Qaeda and Taliban linked militants.
"A US drone fired two missiles and destroyed a house. 12 militants were killed in the attack," a senior security official in Peshawar city told AFP.
Two intelligence officials in Miranshah confirmed the attack.