The export-heavy FTSE 100 slipped 0.7pc, taking the shine off strong gains earlier in the week as data showed Japan's April exports fell the most since the global financial crisis with the pandemic slamming demand for cars and industrial materials.
The mid-cap FTSE 250 shed 0.4pc, snapping a four-day winning streak. Real estate, financials and consumer discretionary stocks were among the biggest drags on the index in morning trading.
EasyJet Plc jumped 4.6pc as it said it would restart a small number of flights on June 15, becoming the latest airline to plan for the return of European travel by making face masks mandatory onboard.
"There's a two-way pull in the market between the impact of the monetary stimulus and, at the same time, evidence of a catastrophic slowdown in the global economy," said Richard Dunbar, head of multi-asset research at Aberdeen Standard Investments.
After rallying about 22pc since late March on a raft of global stimulus and, more recently, the easing of coronavirus-induced shutdowns, the FTSE 100 is now only about 21pc below its January record high.
Premier Inn owner Whitbread Plc tumbled 14.7pc to a two-month low after posting a slide in annual profits and announcing a plan to raise 1.01 billion pounds ($1.23 billion) to ride out the looming recession.
Pets At Home declined 12.8pc to the bottom of the FTSE 250 after forecasting first-half pretax profit to be sharply lower than last year.
Car dealer Inchcape Plc fell 4.3pc as it posted a slump in April revenue and said the global economic impact of the lockdowns would be felt until 2021.