Coach Fernando Santos kept faith largely with the squad that stunned hosts France last summer to win the Euros thanks to an extra-time strike from Eder.
But the forward paid the price for a poor season with the French side Lille and was replaced in the 24-man squad by Porto's Andre Silva.
Portugal play Mexico, hosts Russia and New Zealand in Group A at the Confederations Cup, which begins on June 17.
Before that the same squad will play a World Cup qualifier at Latvia on June 9.
Portugal squad
Goalkeepers: Rui Patricio (Sporting), Beto (Sporting), Jose Sa (Porto)
Defenders) : Nelson Semedo (Benfica), Cedric Soares (Southampton/ENG), Pepe (Real Madrid/ESP), Bruno Alves (Cagliari/ITA), Luis Neto (Zenith/RUS), Jose Fonte (Southampton/ENG), Raphael Guerreiro (Borussia Dortmund/GER), Eliseu (Benfica)
Midfielders: William Carvalho (Sporting), Danilo Pereira (Porto), Joao Moutinho (Monaco/FRA), Pizzi (Benfica), Joao Mario (Inter Milan/ITA), Andre Gomes (Barcelona/ESP), Adrien Silva (Sporting), Bernardo Silva (Monaco/FRA)
Attackers: Cristiano Ronaldo (Real Madrid/ESP), Ricardo Quaresma (Besiktas/TUR), Gelson Martins (Sporting), Andre Silva (Porto), Nani (Valencia/ESP)