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London's benchmark FTSE 100 index fell 0.3 percent from its record closing level on Tuesday to open at 7,499.84 points.
In the eurozone, Frankfurt's DAX slid 0.8 percent to 12,700.12 points and the Paris CAC 40 lost 0.6 percent to 5,375.4.
The French index was dragged down by video game publisher Ubisoft, whose shares slumped six percent after the group announced worse-than-expected losses.