The dollar surged to its highest in nearly 14 years on expectations of rate increases by the Federal Reserve next month and in 2017.
CBOT December wheat settled down 5-3/4 cents at $4.01-1/2 per bushel.
Prospects for deliveries against the December contract on first notice day on Nov. 30 added pressure.
K.C. December hard red winter wheat ended down 1 cent at $4.15-1/2 a bushel while MGEX December spring wheat closed up 1/4 cent at $5.27-1/4.
There was additional pressure from forecasts for much-needed rains in the Mississippi River Delta soft red winter wheat region in the coming days. But traders continue to monitor dry conditions in the southern Plains hard red winter wheat belt.
US markets, including the CBOT, will be closed on Thursday for the Thanksgiving holiday, with trade resuming on Friday at 8:30 a.m. CST (1430 GMT).