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The unmanned aircraft fired two missiles, hitting a house in Shin Warsak, the officials told AFP.
"Two missiles were fired at the house of a tribal elder where local militants were present," one security official told AFP on the condition of anonymity as he is not authorised to speak to media.
"Four dead bodies have been recovered and two are injured," the official added.
The security official said initial reports suggested that a group of local militants were present in the house at the time of the attack.
Copyright AFP (Agence France-Presse), 2011