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The People's Bank of China set the midpoint at 6.1497 per dollar, down 0.06 percent from the previous fix.
It was the weakest level since Sept. 9.
Spot yuan changed hands at 6.1353 near midday, down 0.01 percent from Wednesday's close at 6.1346.
The yuan traded at a narrow range between 6.1344 and 6.1372 in morning trade.