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According to reports in British media, Shahbzada Muhammed Imran, 27, of Bradford, and Ahmed Din Sayed Khayel, 35, of London, were found dead on New Lane, Tong, in Bradford, last Tuesday night.
Police said both had serious head injuries.
Arab Sultana, 63, and Kainet Bibi, 27, who are mother-in-law and daughter-in-law are also charged with destroying or concealing evidence in addition to being accused of men's murder.
Both were remanded in custody and will appear before Bradford crown court.