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The three unidentified Palestinians were travelling in a car that was targeted by Israeli aircraft, the medics and witnesses said.
Three other Israeli raids hit a smuggling tunnel near Rafah, the Jabaliya refugee camp in the north of the Gaza Strip and a car east of Gaza City, without claiming any victims, the sources said.
The latest deaths brought to 16 the number of those killed in Israeli reprisal attacks after an anti tank missile was fired at an Israeli school bus on Thursday seriously wounding an adolescent.