During his three-day official visit, a decision could be made on how many US troops will stay in Afghanistan after 2014, officials have said.
"President Karzai will hold separate meetings with President Barack Obama and other high-ranking US officials to discuss various key issues," Karzai's office said after his departure.
Talks will focus on security, economic and political transition, equipping and strengthening Afghan forces, efforts to negotiate peace with Taliban-led insurgents and a security agreement with the United States, it said.