Rookie paceman Abul Hasan, who has played four Twenty20 internationals, will also be hoping to make his test debut after being included in the squad on Thursday.
Gazi's selection was a reward for his impressive performance in the ongoing National Cricket League where the 21-year-old claimed 11 wickets in two matches, including a hat-trick, and hit a century.
Pace bowler Rubel Hossain returned to the side, led by stumper Mushfiqur Rahim, after a long injury lay-off.
There was no such joy for former captain Mohammad Ashraful, who was replaced by Naeem Islam In the side.
Khulna hosts the second and final test from November 21.
Squad: Mushfiqur Rahim (captain), Mahmudullah, Tamim Iqbal, Shakib Al Hasan, Zunaed Siddique, Shahriar Nafees, Naeem Islam, Nazimuddin, Nasir Hossain, Elias Sunny, Shahadat Hossain, Rubel Hossain, Abul Hasan, Shohag Gazi.