After returning to Pakistan in the late 1980s, she served two terms as a Member of Parliament to the National Assembly from the constituency of Larkana, Sindh.

Begum Nusrat Bhutto rose to political prominence in the late 1970s and early 1980s, when she led protests and demonstrations against the military dictatorship. Begum Nusrat Bhutto also became a cabinet member.

Begum Nusrat Bhutto, former first lady of Pakistan and the mother of former Prime Minister Shaheed Benazir Bhutto, died at a Dubai hospital on October 23, 2011 at the age of 82.