Among the dead were a woman and her two children, killed when a shell landed on their house in Al-Mashatiyah neighbourhood, said the Syrian Observatory for Human Rights.
The neighbourhoods of Qatarji, Tariq al-Bab and Shaar also came under heavy shelling, the Britain-based watchdog said.
The Syrian Revolution General Council, a network of activists on the ground, reported overnight shelling in the neighbourhoods of Al-Kalassa, Shaar, Sukari and Tariq al-Bab as well as heavy artillery fire aimed at the Bustan al-Qasr and Fardoss districts of Aleppo.
In Furqan district, it said security forces were deployed as a power outage struck in the area.
According to the Observatory, there were 225 people killed on Tuesday, one of the highest tolls in the 17-month revolt. Among the victims were 129 civilians, 50 rebels and 46 soldiers.
It is impossible to verify these figures and the United Nations has stopped maintaining an independent toll.