The benchmark Hang Seng Index closed 150.27 points lower at 18,903.20 on turnover of HK$29.28 billion ($3.78 billion).
The market opened for only the afternoon session owing to a severe typhoon hitting the southern Chinese city.
Chinese shares closed up 0.24 percent. The Shanghai Composite Index added 5.19 points to 2,146.59 on turnover of 46.7 billion yuan ($7.3 billion).