The Hang Seng Index lost 0.67 percent, or 172.50 points, to close at 25,478.88.
The benchmark Shanghai Composite Index lost 0.61 percent, or 15.20 points, to 2,483.09.
The Shenzhen Composite Index, which tracks stocks on China's second exchange, dropped 1.22 percent, or 15.56 points, to 1,264.23.