The haul, which was hidden in a cargo of minerals, would be worth over $160 million in Honduras and $350 million in the United States, Bolivian interior minister Carlos Romero said at a news conference.
Romero said the cocaine had been intercepted in trucks carrying borates along a remote mountain pass that connects Bolivia with Chile's sea ports.
In May, Colombian police confiscated 8 tonnes of cocaine, which officials described as one of the largest in the history of the country.