Alexandru Chipciu, Gabriel Torje and Andrei Prepelita were handed starts in midfield with Claudiu Keseru given the nod up front as Romania seek to bounce back from Friday's opening 2-1 defeat to hosts France.
Switzerland coach Vladimir Petkovic named an unchanged side following Saturday's 1-0 victory over 10-man Albania.
Starting line-ups in the Euro 2016 Group A match between Switzerland and Romania at the Parc des Princes in Paris on Wednesday (1600 GMT kick-off):
Switzerland (4-2-3-1)
Yann Sommer; Stephan Lichtsteiner (capt), Fabian Schaer, Johan Djourou, Ricardo Rodriguez; Granit Xhaka, Valon Behrami; Xherdan Shaqiri, Blerim Dzemaili, Admir Mehmedi; Haris Seferovic
Coach: Vladimir Petkovic
Romania (4-2-3-1)
Ciprian Tatarusanu; Razvan Rat, Vlad Chiriches (capt), Dragos Grigore, Cristian Sapunaru; Andrei Prepelita, Mihai Pintilii; Alexandru Chipciu, Bogdan Stancu, Gabriel Torje; Claudiu Keseru
Coach: Anghel Iordanescu
Referee: Sergei Karasev (RUS)