Coentrao, who returns from injury, makes his return while Real teammate Cristiano Ronaldo leads a strong team that also includes returning quartet Hugo Almeida, Antunes, Eliseu and Ventura.
Portugal are currently second in Group I in Euro qualifying with six points, one behind leaders Denmark but with a game in hand, while Serbia have just one point from three matches.
Squad
Goalkeepers: Anthony Lopes (Lyon/FRA), Rui Patricio (Sporting Lisbon), Ventura (Belenenses)
Defenders: Antunes (Dynamo Kiev/UKR), Jose Bosingwa (Trabzonspor/TUR), Bruno Alves (Fenerbahce/TUR), Cédric (Sporting Lisbon), Eliseu (Benfica), Fabio Coentrao (Real Madrid/ESP), Pepe (Real Madrid/ESP), Jose Fonte (Southampton/ENG), Ricardo Carvalho (Monaco/FRA)
Midfielders: André Gomes (Valencia/ESP), Joao Mario (Sporting Lisbon), William Carvalho (Sporting Lisbon), Joao Moutinho (Monaco/FRA), Tiago (Atletico Madrid/ESP)
Forwards: Cristiano Ronaldo (Real Madrid/ESP), Danny (Zenit St Petersburg/RUS), Eder (Braga/POR), Hugo Almeida (Kouban Krasnodar/RUS), Nani (Sporting Lisbon), Ricardo Quaresma (Porto), Vieirinha (Wolfsburg/GER)