The world number five will tackle world number 47 Young in the first match of the tie at Glasgow's Emirates Arena, where the 27-year-old Scot can expect boisterous support.
The USA's leading player, world number 20 John Isner, then tackles James Ward, before top-ranked doubles pairing Bob and Mike Bryan challenge Murray's brother Jamie and Dominic Inglot in Saturday's doubles.
In the penultimate singles match on Sunday, Andy Murray faces big-serving Isner before the tie closes with a showdown between Ward, the world number 111, and Young.
Captained by Jim Courier, the USA are bidding to avenge their 3-1 loss to the British on the San Diego clay at the same stage of last year's tournament.
Great Britain, beaten 3-2 by Italy in last season's quarter-finals, trail the USA 11-8 in Davis Cup encounters.
Draw made on Thursday for this weekend's Davis Cup World Group first-round tie between Great Britain and the United States at the Emirates Arena in Glasgow:
Friday (from 1300 GMT)
Andy Murray (GBR) v Donald Young (USA)
James Ward (GBR) v John Isner (USA)
Saturday (from 1300 GMT)
Dominic Inglot/Jamie Murray (GBR) v Bob Bryan/Mike Bryan (USA)
Sunday (from 1300 GMT)
Andy Murray (GBR) v John Isner (USA)
James Ward (GBR) v Donald Young (USA)