At Ndola, Zambia.
Zesco Utd (ZAM) 1 (Zulu 28) Mbabane Swallows (SWZ) 0
Zesco win 2-1 on aggregate
At Bamako, Mali
Kaloum (GUI) 1 (Kassongo 45) Sewe Sport (CIV) 1 (Guinza 74)
Kaloum win 3-2 on aggregate
Note: match moved from Guinea because of Ebola epidemic
At N'Djamena
Foullah Edifice (CHA) 3 USM Alger (ALG) 1 (Laifaoui 7)
USM win 4-3 on aggregate
At Ouagadougou
Etoile Filante (BUR) 0 Pikine (SEN) 0
Pikine win 1-0 on aggregate
At Zanzibar
KMKM (ZAN) 1 (Mwalim 69) Al-Hilal (SUD) 0
Hilal win 2-1 on aggregate
At Blantyre
Big Bullets (MAW) 2 (Limbani 35, Kumwenda 42) Fomboni Moheil (COM) 2 (Alphonse 52, Madi 56-pen)
Bullets win 3-2 on aggregate
At Kinshasa
Sanga Balende (COD) 2 (Mukundji 35-pen, Limbombe 42) Recreativo Libolo (ANG) 0
Balende win on away goals after 3-3 aggregate tie
At Douala, Cameroon
Cosmos Bafia (CMR) 3 (Ekamba 33, Tombi 70, 90) KCCA (UGA) 0
Bafia win 3-1 on aggregate
At Omdurman, Sudan
El-Merrikh (SUD) 3 (Abdel Gadir 10, Abdullah 85, Wanga 90+2) Azam (TAN) 0
Merrikh win 3-2 on aggregate
At Luanda
Kabuscorp (ANG) 1 (Meyong 13) Lydia Academic (BDI) 0
Kabuscorp win 1-0 on aggregate
At Lome
Semassi Sokode (TOG) 1 (Rafiou 88) Ela Nguema (GEQ) 0
Sokode win 2-1 on aggregate
At Dahir Bar, Ethiopia
St George (ETH) 2 (Assefa 38, Girma 68) El-Eulma (ALG) 1 (Mbang 74)
Eulma win on away goals after 2-2 aggregate tie
At Cotonou
Buffles Borgou (BEN) 0 Enyimba (NGR) 1 (Abalaogu 59)
Enyimba win 4-0 on aggregate
At Alexandria, Egypt
Smouha (EGY) 1 (Amin 53-pen) Al-Ahly Tripoli (LBA) 0
Smouha win 5-3 on penalties after 1-1 aggregate tie
At Antananarivo
CNaPS Sport (MAD) 3 (Ralaidimy 7, Vonimbola 37, 44) Gor Mahia (KEN) 2 (Abondo 29, Odhiambo 90)
Gor win on away goals after 3-3 aggregate tie
At Kigali
APR (RWA) 2 (Mubumbyi 84, Mugiraneza 87) Liga Muculmana (MOZ) 1 (Mustafa 48)
APR win 2-1 on aggregate
At Tetouan, Morocco
Moghreb Tetouan (MAR) 3 (Iajour 12, Aberhoune 26, Naim 78) CO Bamako (MLI) 0
Tetouan win 3-2 on aggregate
At Kano, Nigeria
Kano Pillars (NGR) 3 (Muhammed 38, 89, Hassan 90) Al-Malakia (SSD) 0
Pillars win 5-0 on aggregate
At Gaborone
Township Rollers (BOT) 0 Kaizer Chiefs (RSA) 1 (Nkosi 28)
Chiefs win 3-1 on aggregate
At Brazzaville
Diables Noirs (CGO) 2 (Ebengo 82, Nzete 88) Raja Casablanca (MAR) 2 (Mabide 41, Osaguona 54)
Raja win 6-2 on aggregate
At Pretoria
Mamelodi Sundowns (RSA) 3 (Moriri 7-pen, 53, Mashego 89) St Michel Utd (SEY) 0
Sundowns win 4-1 on aggregate
At Maseru
Bantu (LES) 0 Mangasport (GAB) 1
Mangasport win 2-0 on aggregate
At Niamey
AS Garde Nationale (NIG) 1 (Talatou 61) Stade Malien (MLI) 1 (Bangoura 81)
Stade win on away goals after 1-1 aggregate tie
At Bamako
Barrack Young Controllers (LBR) v Real Banjul (GAM) (first leg: 1-1)
Note: match postponed after Controllers refused permission to stage match in Mali because of Ebola virus fears
Note: Asante Kotoko (GHA) received a walkover when East End Lions (SLE) withdrew
Byes: Esperance, CS Sfaxien (both TUN), Coton Sport (CMR), AC Leopards (CGO), Al-Ahly (EGY), Entente Setif (ALG, holders), TP Mazembe (COD)