England, who have already conceded a decisive 2-4 lead in the series, will seek a consolation win ahead of the World Cup that starts in Australia and New Zealand on February 14.
A large crowd is expected at the Premadasa stadium to cheer veterans Kumar Sangakkara and Mahela Jayawardene in their last one-day international on home soil.
Jayawardene, who has already retired from Tests, will hang up his boots after the World Cup. Sangakkara too will quit one-dayers after the tournament, although he remains non-committal about his future in Tests. England: Alastair Cook (capt), Alex Hales, Moeen Ali, James Taylor, Joe Root, Eoin Morgan, Jos Buttler, Chris Woakes, Chris Jordan, James Tredwell, Harry Gurney.
Sri Lanka: Angelo Mathews (capt), Mahela Jayawardene, Tillakaratne Dilshan, Kumar Sangakkara, Seekugge Prasanna, Lahiru Thirimanne, Dinesh Chandimal, Thisara Perera, Jeevan Mendis, Suranga Lakmal, Dilruwan Perera.
Umpires: Ranmore Martinesz (SRI) and Rod Tucker (AUS)
TV umpire: Bruce Oxenford (AUS)
Match referee: David Boon (AUS)