South Africans lead the 5-match series by 2-1.
Fast-bowler Umar Gul, who missed the third ODI due to a knee injury, has been ruled out of the series.
South Africa : Graeme Smith, Hashim Amla, Colin Ingram, AB de Villiers, David Miller, Farhaan Behardien, Ryan McLaren, Robin Peterson, Dale Steyn, Kyle Abbott and Morne Morkel.
Pakistan: Nasir Jamshed, Mohammad Hafeez, Kamran Akmal, Younis Khan, Misbah-ul-Haq, Shoaib Malik, Shahid Afridi, Umar Gul, Saeed Ajmal, Junaid Khan, Sohail Tanvir.