Diego Simeone's side travel to relegation-threatened Valladolid knowing that if they better Real Madrid's result against Villarreal, they will be crowned champions.
"It's a final against Valladolid, with two sides fighting for their own different, but important, objectives and we will both give absolutely everything they've got to achieve it," Simeone told a news conference.
The Catalans practically surrendered their chances of catching La Liga leaders Atletico Madrid after drawing 3-3 at Levante on Tuesday and trail them by four points with two games left.
"It's not fair that one day everything seemed perfect and two weeks later everything is horrible."
But VAR prompted referee Juan Martinez to check an Eder Militao handball a few seconds before, with a huge decision seeing Madrid's penalty cancelled and a spot-kick awarded to Sevilla instead.
Simeone, however, insisted he would not change his usual set-up for a more attacking one.
"Sometimes it's gone really well and sometimes it hasn't. We don't change a lot. We'll try and play using the good points of how we've been playing up to now.
He can also finally count on a fully fit Eden Hazard, who was in lively form in Saturday's 2-0 win over Osasuna and is in line to start at the ground which he called home for seven years before switching from Chelsea to Real in 2019.
Six minutes later, Barca were in front, Griezmann finishing after De Jong timed his run perfectly to meet Alba's floated cross, only for his header to be palmed by Cillessen into Griezmann's path.
After missing the last nine games in all competitions through injury, Ramos returned to full training on Friday and is available for selection for Saturday's La Liga meeting with Osasuna.
"He's training with us and that means he's able to play too," Zidane told a news conference.
