"By all accounts it seems that (by) the end of June, about 70% of the population should be vaccinated at least with the first jab," Lagarde told an online event.
"This evidence suggests that we should avoid withdrawing policy support - either deliberately or by tolerating adverse spillovers - until the output gap is closed and we see inflation sustainably back at 2%," Panetta said in a speech.
IHS Markit's flash Composite PMI Index, seen as a good guide to economic health, rose to 53.7 from March's 53.2, confounding expectations in a Reuters poll for a dip to 52.8.
Germany's 10-year government bond yield, the benchmark of the euro area, fell 1 basis point at -0.27%.
The ECB decided to continue running its Pandemic Emergency Purchase Programme (PEPP) at its current clip this quarter to keep borrowing costs stable for governments, companies and households.
While that decision was expected, analysts were awaiting hints about the pace of PEPP after June, after governors including the Netherlands' Klaas Knot raised the prospect of dialling it down.
"We've confirmed that demand for Treasuries is healthy, which means there is no upward pressure on yields," said Junichi Ishikawa, senior foreign exchange strategist at IG Securities in Tokyo.
Stokes had an X-ray and CT scan on Thursday, which had revealed the extent of the damage, the ECB statement said, adding that he will fly home for surgery in Leeds on Monday.
"It's a big blow but it's not the end of the world because Ben Stokes would have needed resting in this difficult scheduling year anyway," former England skipper Nasser Hussain told Sky Sports on Friday.
The ECB is working on creating an electronic form of cash to complement banknotes and coin but a digital euro is unlikely to be a reality for four to five years at a minimum.
The ECB has seen euro area inflation fall short of its near 2% target for eight years and expects to miss the target for years as the bloc emerges from the coronavirus crisis.
Nonetheless, he said there was room to improve guidance the ECB gives the market about how it aims to pursue its inflation target.
"There is demand for very long term debt and not enough supply," Visco, a member of the European Central Bank governing council, told CNN when asked about Italy's latest 50-year BTP bond. On Thursday, the Italian Treasury said foreign investors subscribed 88% of the new bond.
The scheme was launched in October 2019 to help the country's banks offload up to 30 billion euros of bad loans by turning bundles of impaired credit into asset-backed securities that can be sold to investors.
Deputy Finance Minister George Zavvos said that with Hercules-2 the government is determined to see a further reduction of bad loans to enable banks to fund the economy, businesses and households.
"The increase in public debt is inevitable and sensible in the face of this crisis of the century, as long as the expenditures sustainably boost growth," she said.
The money will fund additional grants to businesses forced to close due to coronavirus restrictions and extend an existing debt moratorium for small and medium-sized companies, the state auditor at the Treasury, Biagio Mazzotta, added.
"The next stimulus package will certainly be substantial, I think it will be worth as much as the first one approved this year," Mazzotta said at a conference on the COVID crisis.
Italy started the process of selling new 50-year and 7-year bonds via a syndicate of banks on Wednesday, having flagged the new issues the previous day.
Once recovery starts to take hold and investors buy into risk-bearing instruments, nominal bond yields will inevitably move higher and "no amount" of ECB buying can completely undo that.
Snowball also said the domestic game was projecting losses in excess of 100 million pounds ($137.22 million) by the end of April due to the impact of the pandemic.
The number of new confirmed coronavirus cases in Germany rose the most since Jan. 9, while the number of people with COVID-19 in French intensive care units set a high for 2021.
The European Central Bank may need some time before the recently agreed acceleration in the pace of money printing, ECB President Christine Lagarde said on Thursday.
"In my view, this hybrid model could be a possible compromise way forward, as long as an EDIS with full risk-sharing, covering both liquidity needs and losses in the steady state, remains the end goal," de Guindos said in a speech.