Paul Pogba and Anthony Martial have withdrawn from the France squad for matches against the Netherlands and Uruguay due to injury, the French Football Federation (FFF) said on Monday.
The two Manchester United players arrived at France's Clairefontaine training base but were released following assessment by team doctor Franck Le Gall.
Pogba was diagnosed with a muscular lesion in his left thigh while Martial suffered an adductor issue.
Midfielder Pogba missed United's 3-1 away defeat by Manchester City in the Premier League on Sunday.
Forward Martial played 90 minutes and scored United's goal from the penalty spot in the second half.
The injury setback will be frustrating for Martial, who had fought his way back into the national squad after scoring six goals in his last five league appearances for United.
The pair have been replaced by Tottenham Hotspur midfielder Moussa Sissoko and Arsenal striker Alexandre Lacazette.
World champions France visit the Netherlands in the Nations League on Friday before facing Uruguay in a friendly on Nov. 20.
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