Investors are keen to see the influence of activist investor Ryan Cohen, a co-founder of online pet products shop Chewy who joined the board earlier this year.
But that has changed in recent weeks as expectations for a rapidly improving economy have also raised inflation concerns, possibly denting the attractiveness of equities should yields continue to rise.
The general mood across trading floors is of a blockbuster surge in global growth this year as the rollout of vaccines and easing of lockdowns allow life to return to a semblance of normal.
In Tokyo, e-commerce giant Rakuten skyrocketed 20.72 percent to a day-time upper limit of 1,503 yen and Japan Post gained 1.95 percent to 1,045.5 yen after the companies confirmed reports that the two firms agreed to form a capital alliance.
The Dow Jones Industrial Average fell 23.2 points, or 0.07%, at the open to 32462.4 and the S&P 500 fell 14.8 points, or 0.38%, at the open to 3924.52, while the Nasdaq Composite dropped 175.9 points, or 1.31%, to 13222.813 at the opening bell.
Eyes are now on the European Central Bank's policy meeting later in the day, which will be followed for its outlook on interest rates and its vast bond-buying programme as the world economy recovers from last year's collapse.
Terumo changed its course to fall 0.33% after rising on the news that the medical equipment maker has developed a new syringe that can get seven doses out of each vial of COVID-19 vaccine made by Pfizer Inc.