Pfizer-BioNTech said the deal includes an option for 30 million doses that could bring the US-German venture's total deliveries to Turkey to 120 million doses this year.
Two mass vaccination centres operated by the military in Tokyo and Osaka will open next week and are expected to administer the two-shot Moderna vaccine, initially to the elderly.
The plant, which will produce "mRNA drug substance" and employ 75 new staff, will be brought onto the network by the end of 2021 with an investment of up to $40 million, the statement said.
About 1.4 million in the country of 5.7 million have received both vaccine doses, with efforts so far focusing on vulnerable groups, frontline workers, and those above 45.
Tourism might get a shot in the arm from the European Union, which said it was "fully on track" to ensure a Covid health pass would be ready in June to boost travel.
The Southeast Asian country also reported 2,044 new coronavirus cases, bringing the total number of confirmed infections to 78,855 since the pandemic began last year.
Before Thursday, the largest real-world study of the Pfizer/BioNTec vaccine, also in Israel, was nearly five times smaller, involving 1.2 million people.
President Joe Biden said Tuesday he had not made a decision on whether to support a vaccine waiver, but that the United States was moving "as quickly as we can" to export doses.
Pfizer has earned $3.5 billion in the first quarter of 2021, as the ramped up sales of the COVID-19 vaccine boosted its projected annual earnings to $26 billion.
The American pharmaceutical company announced on Tuesday that it has raised its annual revenue guidance to up to $72.5 billion, up from $61.4 billion, predominantly due to the contractual delivery of 1.6 billion vaccine doses in 2021.
"Our first formulation had to be stored and shipped at minus 80 degrees. We have now, in the meantime, a formulation which is not yet approved... which can be stored at two to eight degrees," Sahin told a Financial Times conference panel, adding that data packages were being prepared for regulators.
The EU currently has four vaccines currently authorised by its European Medicines Agency: from BioNTech/Pfizer, Moderna, AstraZeneca and Johnson & Johnson.
This is the third contract sealed by the bloc with the two companies, which have already agreed to deliver 600 million doses under two previous contracts.