Tuesday's game is the latest episode in a burgeoning rivalry between Italy and Spain with the nations meeting in a fourth consecutive European Championship
"We did not get the result we wanted and we leave the competition sooner than expected," Ronaldo admitted as his side failed to match their 2016 exploits.
Despite having just 2,500 tickets for the 22,500 crowd limited by coronavirus restrictions, Scottish fans have already descended on London in their thousands.
Roberto Martinez's side are one of the clear favourites for Euro 2020 thanks to a host of star names who have propelled the Red Devils to the top of the FIFA rankings.